Yintoni indima ye-polydeoxyribonucleotide (pdrn) ekunyangeni inxeba?

 I-Polydeoxyribonucleotide (PDRN) ivela njenge-molecule ye-bioactive ethembisayo kwiindawo zokuphulukisa amanxeba kunye nokuvuselelwa kwezicubu. Ithathwe ngokuyinhloko kwi-DNA fragments, i-PDRN yenza iziphumo zayo zonyango ngokuyinhloko ngokusebenzisa i-adenosine i-A2A receptors, leyo ivuselela ukuveliswa kwe-vascular endothelial growth factor (VEGF) kwaye imodareyithe i-cascade evuthayo. Ezi zenzo ezidibeneyo zikhuthaza i-angiogenesis, ukuphucula i-collagen synthesis, kunye nokuxhasa ukwanda kwamaselula - zonke ezo zibaluleke kakhulu ukulungiswa kwezicubu ezisebenzayo. Uphuhliso lwakutsha nje lugxininisa amandla ayo kungekuphela nje ukukhawulezisa ukuphiliswa kwamanxeba abukhali kwaye angapheliyo kodwa kunye nokuphucula iziphumo kwizicelo zokuvuselela amayeza, njengokubuyiselwa kwezicubu ze-ischemic kunye nokulungiswa kweemeko ezidityanisiweyo.

Ukuqonda iPDN

PDRN okanye Polydeoxyribonucleotide, yimolekyuli eyenzeka ngokwemvelo evela kwi-salmon ye-DNA. Ifumene ingqwalasela ebalulekileyo kumayeza obuhle kunye neenkalo zokuthambisa ngenxa yeempawu zayo zokuvuselela. I-PDRN isebenza kumgangatho weselula, ukukhuthaza ukulungiswa kwezicubu, ukuphucula ukuphulukiswa kwesilonda kunye nokuvuselela ulusu ngokukhuthaza ukukhula kweeseli kunye nokwanda.

I-PDRN ifundwe ngeenjongo ezahlukeneyo zonyango, ngakumbi ukulungiswa kwezicubu, ukuvuselelwa kwesikhumba, kunye nokulawulwa kwamanxeba angapheliyo. Isebenzisa iziphumo zayo zebhayoloji ikakhulu ngeendlela ezimbini:

Ukusebenza kwe-adenosine A2A receptors, ekhokelela kwiimpembelelo ezichasayo kunye ne-pro-angiogenic.

Ukuvuselela indlela yokusindisa, ukubonelela ngee-nucleotides ze-DNA synthesis kunye nokwanda kweeseli.

IiNdlela zokuSebenza

ukuHlaziywa ngokutsha kweSelula: PDRN yenza i-adenosine receptors, edlala indima ebalulekileyo kwimetabolism yeselula kunye nokuvuselelwa kwezicubu. Oku kusebenze kukhokelela ekwandeni komsebenzi we-fibroblast, ukuphucula i-collagen synthesis kunye nokukhuthaza ukulungiswa kwesikhumba esonakele.

I-Angiogenesis: Enye yeempembelelo eziphawulekayo ze-PDRN kukukwazi ukuvuselela i-angiogenesis-ukwenziwa kwemithambo yegazi emitsha. Le nkqubo ibalulekile ekunikeni izondlo kunye neoksijini eluswini, ukukhawulezisa ukuphiliswa kunye nokuphucula impilo yolusu luphela.

iiPropathi ezichasene nokudumba: I-PDRN ibonisa imiphumo yokuchasana nokudumba ngokumodareyitha i-cytokines evuthayo. Le propati inenzuzo ngokukhethekileyo ekunciphiseni ubomvu, ukuvuvukala kunye nokucaphuka, okubangelwa ukuzola kunye nokubonakala kwesikhumba.

Ukulungiswa kweDNA: Njenge-nucleotide, i-PDRN igalelo kwiindlela zokulungisa i-DNA, iqinisekisa ukunyaniseka kwezinto zofuzo kunye nokuxhasa iinkqubo zendalo zokuvuselela ulusu.

Igrafu engezantsi ibonisa inani elipheleleyo leempapasho ngonyaka ngamnye kwi-Polydeoxyribonucleotide Application in Wound Healing and Tissue Regeneration.

I-PDN inceda njani ulusu?

Ukuveliswa kweCollagen: I-PDRN ivuselela i-fibroblasts, iiseli ezinoxanduva lokuvelisa i-collagen kunye ne-elastin eluswini. I-Collagen ibalulekile ekugcineni ulusu oluthambileyo kunye nokuqina, ukunciphisa ukubonakala kwemigca emihle kunye nemibimbi.

Ukuphucula ukuTyeka kolusu: Ngokuphucula imetabolism yeselula kunye nokukhuthaza ukuvuselelwa kwezicubu, i-PDRN inceda ukuphucula ukuthungwa kwesikhumba ngokubanzi. Inokunciphisa uburhabaxa, igudise iindawo ezingalinganiyo, kwaye inike inkangeleko yobutsha.

Iziphumo zokuchasa ukudumba: I-PDRN ibonakaliswe ukuba ineempawu ezichasayo ukudumba, ezinokunceda ukuthomalalisa ulusu olunomsindo kunye nokunciphisa ububomvu. Oku kuyenza ilungele iintlobo zolusu olubuthathaka ngokunjalo.

Ukufakwa kwamanzi kunye noKulula: I-hydration ephuculweyo yenye inzuzo yePDN. Iphucula ukugcinwa kokufuma kwesikhumba kunye ne-elasticity, okukhokelela kwi-plumper kunye nebala elithambileyo.

 

 

Ngawaphi amalungu anokunyangwa ngePdrn?

* ubuso - ukuphucula inkangeleko yobuso, indawo ejikeleze amehlo.

*intamo kunye ne-decolletage - iinaliti ze-pdrn zinceda ukunciphisa imibimbi kunye nemigca emihle entanyeni nakwindawo ye-décollete.

*i-scalp-i-pdrn bio-stimulating properties iyenza ibe luncedo kunyango lwe-scalp njengokulahleka kweenwele kunye nokubhitya.

 *isisu kunye namathanga-pdrn esetyenziselwa ukunciphisa i-cellulite kunye nokuphucula ukuthungwa kwesikhumba kwisisu kunye namathanga.

 

Ukusetyenziswa kwe-PDRN ekuPhiliseni amanxeba

1. Izilonda zeeNyawo zeDiabetes

 

Izilonda zesifo seswekile ziyaziwa ngokuba nzima ukunyanga ngenxa yokuphazamiseka kwe-angiogenesis kunye nokungaphenduli kakuhle kwamajoni omzimba. Izilingo zeklinikhi zibonise ukuba i-PDRN ikhawulezisa ngokukhawuleza ukuphilisa kwizilonda zeenyawo zesifo sikashukela ngokuphucula i-angiogenesis kunye nokunciphisa ukuvuvukala. Izigulane zinyangwa nge PDRN ubonise ukuncipha kobungakanani bezilonda ngokukhawuleza xa kuthelekiswa nokhathalelo oluqhelekileyo.

2. Ukutshiswa Kokwenzakala

Amanxeba atshileyo adla ngokufuna ukuphinda uqhawuke kwakhona ngokukhawuleza ukuze kuthintelwe usulelo kunye namanxeba. Uphononongo lubonisa ukuba i-PDRN ikhuthaza ukwanda kweeseli ze-epithelial, i-collagen synthesis, kunye ne-angiogenesis, ngaloo ndlela ikhawuleza ukuvalwa kwamanxeba okutshisa kunye nokuphucula umgangatho wolusu emva kokuphiliswa.

3. Amanxeba asemva kotyando

I-PDRN iye yavavanywa kwizicwangciso zasemva kokuhlinzwa, ngakumbi emva kweenkqubo zokuthambisa kunye nokuvuselela. Ikhono layo lokunciphisa ukuvuvukala kunye nokukhuthaza ukuchithwa kwe-collagen kukhokelela ekuphuculeni ukubonakala kwesikhumba kunye nokunciphisa ixesha lokubuyisela.

4. Amanxeba angapheliyo kunye nezilonda zoxinzelelo

Izigulana ezisele zikhulile nezingashukumiyo zihlala zinezilonda ezingapheliyo ezifana nezilonda zoxinzelelo. Iziphumo ze-PDRN zokuvuselela kunye ne-angiogenic zixhasa ukuphiliswa kwiimeko ezinjalo, nalapho unyango oluqhelekileyo lusilela. Iingxelo zeklinikhi zibonisa ukuphuculwa okubalulekileyo ekuvaleni isilonda kunye nokuvuselelwa kwezicubu.

5. Iimeko ze-Ischemic

Kwiimeko apho ukuhamba kwegazi kuphazamisekile (njenge-peripheral artery disease), i-PDRN inceda ngokukhuthaza i-angiogenesis kunye nokulungiswa kwezicubu. Oku kwenza ukuba kube yindlela yonyango exabisekileyo ngaphaya kwe-dermatology, ukwandisa kwi-vascular and regenerative.

 

 

isiphelo

 

I-Polydeoxyribonucleotide (PDRN) kuye kwavela njengekhompawundi enamandla ye-bioactive ekuphulukiseni isilonda kunye neyeza lokuvuselela. Ngokusebenzisa i-adenosine A2A receptor, ukuvuselela i-angiogenesis, ukukhuthaza ukwanda kwe-fibroblast kunye ne-collagen synthesis, kunye nokubonelela nge-nucleotides nge-DNA salvage pathway, i-PDRN ikhawuleza ukulungiswa kwezicubu kwizilonda ezibukhali kunye nezingapheliyo. Ubungqina bezonyango buxhasa ngamandla ukusebenza kwayo kwizilonda zesifo seswekile, ukutshisa, amanxeba otyando, kunye neemeko ze-ischemic.

Njengoko uphando luqhubela phambili, iPDRN inokuba lilitye lembombo kukhathalelo lwenxeba lwangoku kunye namayeza okuhlaziya, enika ithemba kwizigulana ezinengxaki yokupholisa amanxeba.

 

Ucaphulo

[1] Iziphumo zonyango lwe-polydeoxyribonucleotide kwi-in vitro neuronal imodeli ye-ischemia / ukulimala kwakhona. Iingxelo zeSayensi (2023).

[2] I-Polydeoxyribonucleotide iphucula i-IL-1β-i-induced impairment of chondrogenic differentiation in human bone marrow-derived mesenchymal stem cells. Iingxelo zeSayensi (2024).

[3] I-injection hyaluronic acid-Polydeoxyribonucleotides (HA-PDN) i-crosslinked hydrogel njenge-dermal filler. Ijenali yePolymer yaseYurophu (2024).