Yintoni umsebenzi we-ergothioneine?

Kumhlaba omkhulu weekhompawundi zendalo ezineziphumo ezinamandla zebhayoloji, i-ergothioneine ivela njengemolekyuli enomdla enezibonelelo ezifikelela ngokubanzi kwimpilo yabantu. Ngelixa ingaziwa ngokubanzi njengeVithamin C okanye i-CoQ10, izazinzulu kunye neempawu zezempilo ziye zaya zijika ingqalelo yazo kwi-ergothioneine ngeempawu zayo ezikhuselayo ezikhethekileyo kunye nomsebenzi ekujoliswe kuwo kwiindawo ezinoxinzelelo oluphezulu lomzimba.

Kule posi ibanzi yebhlog, siza kuhlola yonke into ekufuneka uyazi—ukusuka kwisayensi esemva komsebenzi we -ergothioneine ukuya kwizicelo zayo ezisebenzayo kwizongezo, ukhathalelo lolusu, kunye nokuthintela izifo.

Yintoni Ergothioneine?

I-Ergothioneine (EGT) yi-amino acid equlathe i-sulfur efumaneka kwi-histidine. Yenziwa kuphela yifungi kunye neebhaktheriya ezithile kwaye ayiveliswa ngumzimba womntu. Nangona kunjalo, abantu bayayifunxa i-ergothioneine ngokutya, ngakumbi kwiikhowa, iimbotyi ezimnyama, ii-oats, kunye nenyama ethile.

Enye yezona zinto ziphawulekayo ze-ergothioneine kubukho beprotheni ye-transporter ekhethekileyo, eyaziwa ngokuba yi-ETT (Ergothioneine Transporter) okanye i-OCTN1, evumela umzimba ukuba ukhethe ngokufanelekileyo kwaye uqokelele i-EGT kumalungu abalulekileyo kunye nezicubu ezisengozini yoxinzelelo lwe-oxidative-kuquka isibindi, izintso, ithambo, ithambo kunye nomongo.

Oku kusixelela into ebalulekileyo: umzimba uqaphela i-ergothioneine njengemolekyuli ebalulekileyo yebhayoloji.

Imisebenzi engundoqo ye-Ergothioneine

1. I-Antioxidant enamandla kunye neyodwa

Umsebenzi ophambili kunye nophandwa kakuhle we-ergothioneine yindima yayo njenge-antioxidant enamandla. Ikhusela iiseli kunye nezicubu kuxinzelelo lwe-oxidative, olubangelwa ukuqokelela kweentlobo ze-oxygen esebenzayo (ROS) okanye i-radicals yamahhala. Ngokungafaniyo ne-antioxidants ezininzi, i-ergothioneine:

• Izinzile kakhulu kwaye ayiqhekeki ngokulula.

• Ayibi yi-pro-oxidant phantsi koxinzelelo, isiphene sezinye i-antioxidants.

• Inokuhlaziya kwaye iqhubeke nokusebenza ngaphandle kokuphelelwa ngokukhawuleza.

• Isebenza ngokubambisana namanye ama-antioxidants afana ne-Vitamin C kunye ne-glutathione.

Oku kuyenza ibe ngumkhuseli weselula othembekileyo nohlala ixesha elide.

 

 

2. Ikhusela iMitochondria kwi-Oxidative Damage

IMitochondria ziindawo zamandla zamandla kwiiseli zethu. Nangona kunjalo, bavelisa i-ROS njengemveliso yemveliso yamandla. Ukuba ayilawulwa, ezi zi-ROS zingonakalisa i-DNA ye-mitochondrial kunye nokuphazamiseka komsebenzi, okukhokelela ekugugeni nasekuguleni.

I-Ergothioneine iqokelelana kwi-mitochondria kwaye inceda ekuthomalaliseni ezi ROS, igcine ulungelelwano lwamandla kwaye inciphise ukudinwa kweeseli. Le ndima ibaluleke kakhulu kwizicubu ezifuna amandla amaninzi njengengqondo, intliziyo kunye nemisipha.

 

 

3. Iyanciphisa ukuvuvukala

Ukudumba okungapheliyo kunxulunyaniswa phantse naso sonke isifo esikhulu-ukusuka kwisifo sentliziyo ukuya kwi-neurodegeneration kunye nokuphazamiseka kwesikhumba. I-Ergothioneine ibonakaliswe ukunciphisa i-cytokines e-pro-inflammatory kunye ne-block inflammatory pathways.

Umsebenzi wayo ochasayo unceda:

• Ukuthomalalisa ukudumba kwesikhumba kunye novelwano

• Ukunciphisa iimpawu zokudumba kwenkqubo

• Ukuxhasa ukulawulwa komzimba

Oku kuyenza ibe sisithako esinomtsalane kuzo zombini iimveliso zokhathalelo lwesikhumba kunye nezongezo zokutya ezijolise kulawulo lokudumba.

4. I-Metal Ion Chelation

Iintsimbi ezinzima ezifana nentsimbi kunye nobhedu zinokwenza iintshukumo ezivelisa iiradicals zasimahla ezisebenza kakhulu. I-Ergothioneine inekhono elikhethekileyo lokubopha (i-chelate) kwezi ion zetsimbi, ukuzinzisa kunye nokukhusela ekuveliseni uxinzelelo lwe-oxidative.

Lo msebenzi:

• Yehlisa ubutyhefu obubangelwa yintsimbi

• Ixhasa ukuhanjiswa komzimba

• Ikhusela kwiinguqu ze-neurodeergenerative ezinxulumene nokwakhiwa kwesinyithi esinzima

5. Ixhasa i-Immune System

Iiseli zamajoni omzimba, ngakumbi i-phagocytes, zivelisa ukugqabhuka kwe-oxidative ukubulala iintsholongwane. Nangona kunjalo, lo msebenzi we-oxidative ungonakalisa izicubu ezinempilo ukuba awulawulwa.

I-Ergothioneine isebenza njengomlawuli, ilinganisa amajoni omzimba ngoku:

• Ukukhusela iiseli zomzimba kwi-oxidative self-enzakalise

• Ukuxhasa umsebenzi weeseli ezimhlophe zegazi

• Ukumodareyitha iimpendulo ze-immune kukuvuvukala okungapheliyo

Oku kuyenza ibe luncedo kwinkxaso yomzimba, ngakumbi kubantu abalupheleyo okanye abantu abaneemeko ze-autoimmune.

6. I-Neuroprotection

Kwinkqubo ye-nervous, uxinzelelo lwe-oxidative kunye nokudumba ngabona banegalelo elikhulu ekunciphiseni kwengqondo okunxulumene neminyaka kunye nezifo ze-neurodeergenerative ezifana ne-Alzheimer's kunye ne-Parkinson.

Ergothioneine:

• Unqumla umqobo wegazi-ubuchopho

• Iqokelela kwi-neurons kunye neeseli zeglial

• Ikhusela izicubu zobuchopho kumonakalo we-oxidative

• Ukuthintela neuroinflammation

Uphononongo olusakhulayo lucebisa ukuba amanqanaba asezantsi e-ergothioneine anxulunyaniswa nokuphazamiseka kwengqondo kubantu abasele bekhulile, oko kuyenza ibe yinto enokubakho i-biomarker yokuguga kwengqondo.

7. Impilo yesikhumba kunye ne-Anti-Aging

Kwi-skincare, i-ergothioneine isebenza ngolu hlobo:

• I-antioxidant ye-UV ekhuselayo enciphisa ukufota

• Umkhuseli womonakalo weDNA kwiiseli zolusu

• I-collagen-preserver, igcina ulusu luqinile kwaye luselula

• I-hydration enhancer ngokuxhasa umsebenzi wokuthintela ulusu

Ukukwazi kwayo ukungena esikhumbeni kwaye iqokelele kwiiseli ezisengozini yenza ukuba ibe yinto ebalaseleyo yokuchasana nokuguga kwiiserum, i-creams, kunye ne-sunscreens.

8. Ukuchasa ukuguga kwiNqanaba leSelula

Ukwaluphala ngokuyintloko kukwanda komonakalo weeseli ngokuhamba kwexesha—ingakumbi ngenxa yoxinzelelo lwe-oxidative kunye nokungasebenzi kakuhle kwe-mitochondrial. Imisebenzi ye-Ergothioneine ilwa ngokuthe ngqo nale nkqubo, inceda uku:

• Gcina ingqibelelo yeDNA

• Gcina amandla eselula

• Ukulibaziseka kokubonakala kweeseli (ukuguga kwebhayoloji yeeseli)

Yiyo loo nto i-ergothioneine ngamanye amaxesha ibizwa ngokuba "yivithamin yokuphila ixesha elide," nangona ayikachazwa njenge-vitamin okwangoku.

Izifundo zeNzululwazi ezixhasa imisebenzi ye-Ergothioneine

• I-Biology ye-Radical yamahhala kunye neMithi (2007): Iqinisekisile indima yokukhusela ye-ergothioneine kwi-DNA ye-mitochondrial kunye nokuveliswa kwamandla.

• Ijenali yeCosmetic Dermatology (2016): Ibonise uphuculo kwithoni yesikhumba, i-hydration, kunye ne-elasticity kunye nokusetyenziswa kwe-ergothioneine ye-topical.

• I-Gerontology yoMfuniselo (2016): Kufunyaniswe ukuba amanqanaba aphezulu e-ergothioneine adibaniswa nokuncipha kwamanqaku okuguga kubantu abadala.

• I-Antioxidants kunye ne-Redox Signaling (2012): Ibonise indima yayo ekukhuseleni i-neuroinflammation kunye nomonakalo oxidative kwingqondo.

Izicelo kuShishino

I-Ergothioneine okwangoku isetyenziswa okanye ihlolwa apha:

Ukutya kunye nezongezo zesondlo:
I-Ergothioneine, njenge-antioxidant yendalo, ihlala yongezwa ekutyeni kunye nezongezelelo zesondlo ukunyusa umthamo we-antioxidant wemveliso kunye nokwandisa ubomi bayo beshelufu. Inceda ukukhusela iiseli kumonakalo we-oxidative kunye nokuphucula impilo yonke.

IiMveliso zokuKhathalela ulusu kunye nezithambiso:
Kwiimveliso zokhathalelo lwesikhumba, i-ergothioneine isetyenziswa njengesithako se-antioxidant ukunceda ukukhusela ngokuchasene noxinzelelo lokusingqongileyo kunye nomonakalo omkhulu wolusu. Inokuphucula ukuhanjiswa kwesikhumba, ukunciphisa ukuvuvukala, kwaye kunokukhuthaza ukuphiliswa kolusu kunye nokuvuselelwa.

Indawo yezonyango:
I-Ergothioneine ibonise amandla okukhusela kwi-neuroprotection kwezinye izifundo kwaye ingasetyenziselwa ukunyanga izifo ze-neurodeergenerative ezifana ne-Alzheimer's kunye ne-Parkinson. Iimpawu zayo ze-antioxidant ziye zatsala umdla wophando kwizifo ezingapheliyo ezifana nesifo senhliziyo kunye nesifo sikashukela.

Isondlo sezemidlalo:
Kwiimveliso zezondlo zezemidlalo, i-ergothioneine ingasetyenziselwa njenge-antioxidant yokunceda iimbaleki zikhusele ngokuchasene noxinzelelo lwe-oxidative olubangelwa ukuzivocavoca, ukuphucula ukubuyiswa, kunye nokuphucula ukusebenza kwezemidlalo.

ULimo kunye noKhuseleko lweZityalo:
I-Ergothioneine nayo idlala indima ebalulekileyo kwizityalo kwaye ingasetyenziselwa ukuqinisa ukukhuseleka kwezityalo, ukunceda izityalo ukumelana noxinzelelo lwendalo kunye nesifo.

Ubume bayo bemisebenzi emininzi kunye nokuzinza kuyenza ibe sithako seprimiyamu yokwenziwa kwezinto ezintsha kuwo onke amacandelo ezempilo.

isiphelo

Umsebenzi we -ergothioneine ulula kodwa unamandla: ukhusela iiseli kunye nezicubu ekonakaleni, unceda ekulawuleni ukudumba, ugcina impilo ye-mitochondrial, kwaye uxhasa amandla exesha elide. Nokuba isetyenziswa njengesongezelelo okanye isetyenziswe ngaphandle, i-ergothioneine inika iingenelo ezikhethekileyo ezinokuthi zifane nezinye izinto ezimbalwa.

Njengoko isayensi iqhubeka nokuvula iimfihlo zokuguga kwamaselula kunye nesifo esingapheliyo, i-ergothioneine ibonakalisa ukuba ngumhlobo obalulekileyo kwimpilo yabantu, ubomi obude, kunye nokuqina kolusu.

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