ILactoferrin: Yintoni na kwaye kutheni ibalulekile kwiMpilo yakho

Lactoferrin: Isishwankathelo

 

I-Lactoferrin (lactotransferrin), luhlobo lwentsimbi ebopha i-glycoprotein eyeye-transferrin yosapho lwe-iron ebopha imisebenzi emininzi ye-glycoprotein efumaneka ikakhulu kubisi lwe-mammalian kunye nolwelo olwahlukeneyo lomzimba. ILactoferrin ifumene ingqwalasela enkulu kuphando lwesayensi ngenxa yemisebenzi yayo eyahlukeneyo yebhayoloji kunye nokusetyenziswa okunokwenzeka. ILactoferrin inceda ukulawula indlela intsimbi efunxeka ngayo emzimbeni isuka emathunjini. Ikwakhusela kusulelo olusuka kwiibhaktheriya, iintsholongwane, kunye nokungunda. I-Lactoferrin iphezulu kwi-colostrum kunye nobisi, eyafunyanwa kubisi lwebele ngoososayensi i-MONTREUIJ kunye ne-JOHANSONB ngo-1960.

 

I-Lactoferrin (LF) okanye i-lactotransferrin isandula kuba phantsi kokukhanya, ngakumbi ngokubhekisele kubhubhani omtsha we-coronavirus oqale ngo-2019 (COVID-19). Ukutya kunye nezongezo zixhasa amajoni omzimba asebenza kakuhle, kwaye aphembelela ngokufanelekileyo amandla omzimba okulwa usulelo.

 

ILactoferrin ikwayi-immunomodulator elawula ukusebenza kweeseli ezahlukeneyo zokuzikhusela. Ibonisa iipropati ezichasayo ngokucinezela imveliso ye-cytokines e-pro-inflammatory kunye nokukhuthaza ukukhululwa kwee-molecule ezichasayo.

Izibonelelo zeLactoferrin: Yintoni enokwenziwa yiLactoferrin kuMzimba

 

Imisebenzi ephambili yeLactoferrin emzimbeni kukubopha ngentsimbi, kunye nokuhambisa intsimbi kwiindawo ezahlukeneyo zomzimba. Ithathwa njengesisombululo okanye uncedo kuluhlu lweemeko zempilo kunye neenkqubo ezibandakanya ezi zilandelayo.

 

1. Abalindi Kwizifo

 

ILactoferrin licandelo elibalulekileyo elibandakanyeka kwiimpendulo zomzimba. Ukuze kuqondwe ngakumbi, kufanele kuphawulwe ukuba i-iron inendima entsonkothileyo kwinkqubo yomzimba yokuzikhusela. Nangona ibangela kwaye isebenze ukunyuka okukhawulezayo kweeseli zomzimba ngexesha lokuphendula komzimba, isinyithi sikhuthaza ukukhula kwebhaktheriya kunye ne-microbial. Xa umzimba wasemzini uhlasela, umzimba wakho (umkhosi) kunye ne-pathogenic microorganisms (iiarhente ezihlaselayo) zilwela intsimbi, kwaye iiproteni ezinje ngelactoferrin zigcina intsimbi kude ngokukhuselekileyo.

 

Iprotheyini ebophelelayo yentsimbi ikwabonisa ukuziphatha okutshabalalisayo ngokuchasene nemizimba yangaphandle ehlaselayo, njengoko itshabalalisa iindonga ezijikeleze ibhaktheriya. Ukongeza, kucingelwa ukuba i-lactoferrin kubisi lukamama (ingakumbi kwi-colostrum) inceda ukukhusela iintsana ezincancisayo kusulelo.

 

Izifundo ezimbalwa zibonisa ukuba i-lactoferrin inokuthintela usulelo lwe-hepatitis C. Inceda ukunyusa imveliso yeprotein ye-immune system edlala indima ephambili ekulweni i-hepatitis C.

 

2. Ikhuthaza Amathambo Omelele

 

Nangona kukho uphando oluncinci kuyo, kucetyiswa ukuba i-lactoferrin ineempawu zokwakha amathambo ezinokunceda ekomelezeni amathambo kunye nokuthintela i-osteoporosis.

 

Uvavanyo lwaselabhoratri lufumanise ukuba xa idityaniswe neminerali ebizwa ngokuba yi-hydroxyapatite, i-lactoferrin ivuselela ukuveliswa kwee-osteoblasts okanye iiseli ezenza amathambo. Uphononongo lwenziwe kwi-lactoferrin ukukwazi ukunciphisa ukubuyiswa kwamathambo kubasetyhini be-postmenopausal.

 

 

3. Uncedo kwiMpilo entle yegazi

 

ILactoferrin ikwadlala indima ekugcineni impilo yegazi phezulu. Ngokuqinisekisa ukuba i-iron ifunxeka kakuhle emzimbeni, i-lactoferrin inceda ekuveliseni i-hemoglobin's. Ezi zizinto ezikwiiseli ezibomvu zegazi ezinoxanduva lokubonelela ngeoksijini kumalungu abalulekileyo nakwamanye amalungu omzimba. Xa unempilo enhle yegazi, unokulindela ukukhathala okuncinci, kunye namandla amaninzi ngokomzimba nangokwengqondo.

 

4. Ixhasa impilo yesikhumba

 

I-Lactoferrin yi-antioxidant eza kunye ne-antibacterial kunye ne-anti-inflammatory properties. Kungezi mpawu apho i-lactoferrin igcina ulusu lusebenza njengomatshini ofakwe ioyile kakuhle.

 

Njenge-antioxidant, ilwa neeradicals zasimahla ezonakalisa iiseli nto leyo ithetha lukhulu ekugcineni ulusu lusempilweni. Inceda ukuhlaziya iiseli zolusu kwaye igcine umqobo wokhuselo wolusu unjalo. Ngaphandle, ulusu luya kubonakala lusempilweni kwaye luthambile, kwaye amanxeba aya kuphola ngokukhawuleza.

I-Lactoferrin's antibacterial kunye ne-anti-inflammatory properties inceda kakhulu ekugcineni ulusu lucocekile kwi-acne. Oku kuqinisekisa ukuba iibhaktheriya ezibangela i-acne kunye nokuvuvukala kuyancitshiswa.

Uphononongo lwafumanisa ukuba xa zidityaniswe nevithamin E kunye ne-zinc, i-lactoferrin's-acne-clear-clear features ziyaphuculwa kwaye ziyakwazi ukunciphisa izilonda zamaqhakuva, ii-comedones kunye nezilonda zokukrala.

 

imisebenzi

 

I-Lactoferrin yintsimbi ebopha i-glycoprotein kwi-transferrin, egxile kubisi lomntu kunye nolwaluncelisayo kunye nolwelo olwahlukeneyo oluyimfihlo. Nangona kunjalo, umxholo we-colostrum ngowona uphezulu. Inani elincinci le-lactoferrin likwaqulethwe kumphezulu we-mammalian mucosal, iinyembezi, amathe, amasuntswana e-leukocyte, ijusi yepancreatic, i-bile kunye nolwelo lwamathumbu. Inoluhlu olubanzi lwemisebenzi, kubandakanywa inzala, i-bacteriostatic, i-anti-virus, i-immune regulation, ukukhuthaza ukuxutywa kwesinyithi kunye neminye imisebenzi ekhethekileyo ye-physiological.

 

1. Intsholongwane

 

Kuye kwagqitywa ukuba i-lactoferrin i-agent-spectrum bacteriostatic agent, enokuthintela iibhaktheriya ze-Gram-negative ezifuna isinyithi, njenge-coliform, i-Salmonella, njl.; Iyakwazi nokuthintela iibhaktheriya zeGram-positive. Nangona kunjalo, ngokusisiseko ayithinteli ibhaktheriya enemfuno ephantsi yentsimbi, njengebhaktiriya ye-lactic acid.

 

2. IAntiviral

 

UPioneer Biotech nguMvelisi weLactoferrin. Idlala indima enkulu ekuxhathiseni iintsholongwane kwinginginya, kwaye inokuthintela intsholongwane ye-immunodeficiency (HIV), i-cytomegalovirus, iindidi ze-herpesvirus 1 kunye ne-2, i-virus ye-hepatitis C (HCV), intsholongwane yomkhuhlane njalo njalo. Ingcaciso enye yenkqubo ye-antiviral ye-lactoferrin kukuba i-lactoferrin inokudibanisa nentsholongwane kunye neeseli ezibambayo, ukuze ithintele indibaniselwano phakathi kwentsholongwane kunye neeseli ezibambayo kunye nokukhusela ezokugqibela kukwenzakala kwentsholongwane.

 

 

3. Antioxidant

 

Ioksijini engaphezulu kweradicals yasimahla emzimbeni yenza i-lipid peroxide, enokonakalisa iiseli kunye nezicubu. Luphawu lokuguga kunye nezifo. ILactoferrin inokubopha ii-iron kwaye ithintele i-lipid oxidation kunye nokusinda kwinguqu yeoksijini yasimahla ebangelwa zii-iron. Zonke ezi zinto zinokunciphisa umonakalo weeradicals zasimahla kwi-elastin eludongeni lwemithambo, ukuze kuthintelwe kwaye kunyange i-atherosclerosis kunye nesifo sentliziyo.

 

4. Ukulawula ukuphendula komzimba

 

I-Lactoferrin inokudibanisa kunye ne-lymphocytes, i-monocytes, i-macrophages kunye nezinye iiseli ukuze zidlale imisebenzi eyahlukeneyo. I-Lactoferrin inokuphembelela ukusabela komzimba kwi-humoral, ikhuthaze ukwanda kwe-lymphocyte, ilawule ukuveliswa kweeseli zomongo wethambo kunye nokunciphisa ukudumba. Kwangaxeshanye, i-lactoferrin inokubulala iintsholongwane ngokuvuselela ii-neutrophils ukuvelisa iiperoxide. I-Lactoferrin inokuphembelela ukwanda kweeseli ze-mucosal zamathumbu kunye neeseli ze-spleen kwaye ikhuthaze ukuvuthwa kwamajoni omzimba amathumbu.

 

5. Ukuthintela ukuphuhliswa komhlaza

 

I-Lactoferrin yi-in vitro i-antiviral ebanzi ye-antiviral ye-virus yabantu kunye nesilwanyana esekwe kwi-DNA / RNA. Ukumelana ne: i-herpes simplex virus type I and II, i-cytomegalovirus, i-virus yokungabikho komzimba womntu, i-virus ye-hepatitis C, i-hantavirus, i-rotavirus, i-poliovirus yohlobo lwe-I, i-virus ye-syncytial yokuphefumula komntu kunye ne-murine leukemia virus.

 

Inkcazo: https://www.spandidos-publications.com/10.3892/ijo.2021.5265

 

6. Ukulawula ukufunxwa kwentsimbi

 

Njengesixabisi sentsimbi, isiphumo sokufunxa se-lactoferrin singcono kakhulu kuneso se-sulfate ye-ferric. I-Lactoferrin inamandla okubopha kunye nokuthutha intsimbi. Inokukhulula i-iron emva kokufikelela emathunjini omntu, enokuthi iphucule eyona nto ifunxayo kunye ne-bioavailability yentsimbi.

 

7. ILactoferrin yonyango lwe-COVID-19

 

Kutshanje, izazinzulu zaseMelika zisebenzise itekhnoloji yobukrelekrele bokwenziwa ukujonga uninzi lwamachiza anokujongana ne-COVID-19, kubandakanya ne-lactoferrin.

 

Ingcaciso: https://www.spandidos-publications.com/10.3892/etm.2020.9402

 

8. Eminye imisebenzi

 

ILactoferrin inokuthintela amathumba esisu, anjengomhlaza wekoloni kunye nomhlaza wesisu, kwaye inhibit i-tumor metastasis. Ukongeza, i-lactoferrin inokukhuthaza ukukhula kweebhaktheriya eziluncedo ezifana ne-bifidobacteria kunye neLactobacillus emathunjini kwaye inqanda iintsholongwane eziyingozi.

 

Imibuzo Ebuzwa Rhoqo malunga neLactoferrin

 

Ngaba i-lactoferrin inokuthatyathwa ukuba abantu banovelwano lwe-lactose okanye abalwani nobisi?

Kuxhomekeke kumthombo we-lactoferrin. Ukuba yimveliso yelactoferrin ecocwe kakhulu, inokuthatyathwa ngokuzithemba ngabantu abanokunganyamezeli i-lactose okanye ukwaliwa lubisi. Ukuba umthombo ngumthubi, akufuneki usetyenziswe ngabantu abanovelwano okanye abalwani nobisi.

 

Ngaba i-lactoferrin iqulethe isinyithi?

Kwakhona, kuxhomekeke kumthombo we-lactoferrin. Imveliso yelactoferrin ecocwe kakhulu ayinayo intsimbi (ngaphantsi kwe-180 mcg ngegram). Olu hlobo lwe-lactoferrin lubizwa ngokuba yi "apolactoferrin" njengoko ayinayo intsimbi. Kusenokubakho intsimbi xa usebenzisa icolostrum, kodwa ayingomthombo ubalulekileyo.

 

Ngaba i-bovine lactoferrin kufuneka ithathwe njengendlela yokuthintela usulelo?

Ukongezwa nge-lactoferrin ye-bovine kunokuxhasa ukhuselo olukhethekileyo lomkhosi kunye nempilo yonke yomzimba. Ingasetyenziswa njengothintelo nanini na xa amajoni omzimba acelwa umngeni. Kukwanjalo nakwi colostrum yenkomo.

 

Ungayithenga phi I-lactoferrin?

Ungathenga i-lactoferrin kwi-YANGGE BIOTECH INGREDIENTS Inkampani ngumenzi okhokelayo kumzi-mveliso kunye nosasazo lwezongezo zokutya ezicocekileyo. I-YANGGE BIOTECH INGREDIENTS ayilophawu lwabathengi nje. Ikwabonelela ngezithako ezicocekileyo kwezinye iibrendi ezihambisa ukutya kunye nezinye iimveliso ezongezelelweyo. Qhagamshelana yangebiotech.com ukwenza iodolo namhlanje.

 

Ukusonga, iLactoferrin ngokucacileyo ineenzuzo ze-immunological, kunye nokuba nendima ebalulekileyo ye-antibacterial kunye ne-antiviral. Kuba iyaziwa ngokuphazamisana nezinye ii-receptors ezisetyenziswa yi-coronavirus, inokuba negalelo eliluncedo kuthintelo nakunyango losulelo lwe-coronavirus. Inzuzo enokubakho ye-lactoferrin ukukhusela iintsana kubantu abadala abanophuhliso lomzimba kunye neenkqubo zokhuselo ezisisiseko kunye nokufunxa intsimbi kunye neendlela ezichasene nokudumba ziyenza ibe lunyango olunomtsalane kwizicelo ezininzi. Njengenxalenye yeendlela zokuzikhusela zendalo zomzimba, i-lactoferrin ephakamileyo yi-biomarker ye-IBS xa ikwilindle kunye negazi okanye iinyembezi zinokubonisa ezinye izifo. Ukusetyenziswa konyango lwe-lactoferrin kubandakanya impilo yomlomo, impilo yolusu ngakumbi ukuphiliswa kwenxeba, ukwalana, impilo yemiphunga, imetabolism yesinyithi, impilo yelungu lobufazi, impilo esanda kuzalwa, impilo yesisu, impilo yokuphefumla, kunye nempilo yonke yomzimba.