Ngaba i-PQQ ilungile kwingqondo?

Kwicandelo le-neuroscience yesondlo, zimbalwa izinto eziye zatsala umdla omkhulu njengePyrroloquinoline Quinone (PQQ) . Le nto ifumaneka ngokwendalo, efumaneka ekutyeni okuthile kwaye ifumaneka njengesongezelelo sokutya, iye yanconywa njenge-antioxidant enamandla kunye nesikhuthazi se-mitochondrial biogenesis. Kodwa ngaphaya kwemiphumo yayo yempilo, umbuzo omnye uyaqhubeka nokutsala ingqalelo yabaphandi kunye nabathandi bezempilo ngokufanayo: Ngaba i-PQQ ilungile engqondweni?

Impendulo ibonakala inguewe onamandla. Izifundo ezivelayo zibonisa ukuba i-PQQ idlala indima ebalulekileyo ekukhuseleni iiseli zobuchopho, ukuphucula ukusebenza kwengqondo, kunye nokunciphisa umngcipheko wokuhla kwemithambo-luvo. Makhe sijonge nzulu ukuba isebenza njani i-PQQ, kutheni ibalulekile kwimpilo yobuchopho, kwaye yintoni etyhilwa yinzululwazi yangoku malunga neenzuzo zayo ezinokubakho.

Ukuqonda iiMfuno zaMandla zeBrain

Ingqondo yomntu lilungu elidinga amandla. Ngaphandle kokumela kuphela malunga ne-2% yobunzima bomzimba, idla phantse i-20% yamandla omzimba ewonke. La mandla enziwa ikakhulu yi-mitochondria, amagumbi amancinci angaphakathi kweeseli. Njengoko sikhula, umsebenzi we-mitochondrial uthande ukwehla, unegalelo ekudinweni, ukucinga kancinci, ukulahleka kwenkumbulo, kunye nokwanda komngcipheko kwizifo ze-neurodeergenerative.

Kulapho i-PQQ ingena khona. Ngokungafaniyo nee-antioxidants ezininzi ezinciphisa ii-free radicals, i-PQQ inamandla akhethekileyo okukhuthaza ukudalwa kwe-mitochondria entsha - inkqubo ebizwa ngokuba yi-mitochondrial biogenesis. Ngokuphucula ukusebenza kwe-mitochondrial, i-PQQ iqinisekisa ukuba ii-neurons (iiseli zobuchopho) zinobonelelo lwamandla eziludingayo ukuxhasa ukufunda, inkumbulo, kunye nomsebenzi wokuqonda ngokubanzi.

Ixhasa njani iPQQ kwiMpilo yeBrain​​​​​​​

1. I-Mitochondrial Biogenesis kwi-Neurons

Umsebenzi osempilweni we-mitochondrial ubalulekile ekusebenzeni kwengqondo. Uphando lubonisa ukuba i-PQQ inokunyusa ii-genes ezibandakanyeka ekwakhiweni kwe-mitochondrial , inika ii-neurons amandla angakumbi. Oku kwenza i-PQQ ibaluleke kakhulu ekunciphiseni kwengqondo okunxulumene nobudala, apho ukunikezelwa kwamandla kwii-neurons kudla ngokuphazamiseka.

2. Ukhuseleko olunamandla lwe-Antioxidant

Ingqondo isengozini enkulu yoxinzelelo lwe-oxidative , oluyonakalisa ii-neurons kwaye lukhawulezise izifo ze-neurodegenerative ezifana ne-Alzheimer's kunye ne-Parkinson's. I-PQQ isebenza njenge- antioxidant ejikeleza i-redox , oko kuthetha ukuba imolekyuli enye inokuphelisa ii-free radicals ngokuphindaphindiweyo. Oku kuyahlula kwii-antioxidants eziqhelekileyo ezifana ne-vitamin C, enokusebenza kube kanye kuphela ngaphambi kokuba iphele.

3. IFactor yokuKhula kweNerve (NGF) Ukuvuselela

Enye yezona ziphumo zibalaseleyo zePQQ kukukwazi kwayo ukukhuthaza ukuveliswa kwe -nerve growth factor (NGF) . I-NGF yiproteni exhasa ukukhula, ukugcinwa, kunye nokulungiswa kwee-neurons. Ukwanda komsebenzi we-NGF kuthetha unxibelelwano oluqinileyo phakathi kweeseli zobuchopho kunye nokuphuculwa kwe-brain plasticity - amandla okufunda, ukuziqhelanisa, kunye nokwenza iinkumbulo ezintsha.

4. Ukuphuculwa kwengqondo

Izifundo zabantu zibonisa ukuba ukongezwa kwe-PQQ kunokuphucula inkumbulo, ingqalelo, kunye nesantya sokucubungula . Umzekelo, kuvavanyo lweklinikhi lwaseJapan, abathathi-nxaxheba abathathe i-PQQ kangangeeveki ezili-12 bafumene uphuculo olukhulu kwimemori yexesha elifutshane kunye nokucaca kwengqondo xa kuthelekiswa namaqela e-placebo. Xa idityaniswe ne -Coenzyme Q10 (CoQ10) , i-PQQ ibonise uphuculo olukhulu ngakumbi ekusebenzeni kwengqondo.

5. Ukukhuselwa kwi-Neurotoxins

I-PQQ ibonakalise iziphumo zokukhusela kwiiproteni ze-amyloid-beta , iiplaque eziyingozi ezinxulumene nesifo se-Alzheimer. Izifundo zezilwanyana zibonisa ukuba i-PQQ inciphisa ukwakheka kweplaque kwaye ithintela ubuthi be-neurotoxicity, inika ithemba njengendlela yokuthintela i-dementia.

6. Ukuphucula iMood kunye nokulala

Okubangel’ umdla kukuba, ukongezwa kwe -PQQ kukwanxulunyaniswe nomgangatho wokulala ongcono, uxinzelelo oluphantsi, kunye nokulawulwa kwemood okuphuculweyo . Ekubeni uxinzelelo kunye nokungalali kakuhle zizinto eziphambili ezibangela ukuwohloka kwengqondo, oku kwenza i-PQQ ibe sisondlo esixabisekileyo ngakumbi esixhasa ingqondo.

I-PQQ kunye neNgcaciso yeNgcaciso eNxulumene nobudala

Enye yezona ndawo zinomdla kakhulu kuphando lwe-PQQ yindima enokubakho ekucutheni okanye ekuthinteleni izifo ze-neurodeergenerative. Ngelixa kungabikho isongezelelo sonyango, iindlela ze-PQQ - ukusuka ekukhuseleni i-mitochondria ukuya ekunciphiseni umonakalo owenziwe nge-oxidative - zijongana nezinye zezona zizathu zokuwohloka kobuchopho obunxulumene nobudala.

Ngokuxhasa ukusebenza kwe-mitochondrial enempilo, ukunciphisa ukudumba, kunye nokukhusela i-neuron kwiiproteni ezinetyhefu, i-PQQ ibonelela ngeendlela ezininzi zokugcina impilo yengqondo ukuya ebudaleni.

Isebenza njani i-PQQ njengeAntioxidant ebuchotsheni

Ngokungafaniyo nee-antioxidants ezininzi eziphelelwa ngamandla emva kokuthomalalisa i-free radical enye, i-PQQ inamandla amangalisayo okugqitha kwimijikelo emininzi ye-redox . Oku kuthetha ukuba inokuthi ithomalalise iimolekyuli ze-oxidative ngokuphindaphindiweyo ngaphandle kokuba ingasebenzi ngokwayo.

Kwingqondo, oku kubalulekile: ii-neurons zinobuthathaka kakhulu kumonakalo we-oxidative, kwaye uxinzelelo lwe-free radical oluqokelelweyo lunxulunyaniswa kakhulu nokuwohloka kwengqondo kunye nezifo ezifana ne-Alzheimer's. Ngokugcina isikhuselo se-antioxidant esihlala ixesha elide , i-PQQ inceda ii-neurons ukuba zihlale zisebenza kwaye ziqine.

Ingakanani iPQQ oyifunayo?

Izongezo ze-PQQ eziqhelekileyo zibonelela nge-10-40 mg ngosuku, nangona ezinye izifundo zonyango zisebenzisa ukuya kuthi ga kwi-60 mg. Ihlala ithathwa ecaleni kwe-CoQ10, kuba ezi khompawundi zimbini zisebenza ngokubambisana ukukhulisa impilo ye-mitochondrial.

Imithombo yokutya ye-PQQ ibandakanya i-soy ebilisiweyo (i-natto), i-kiwi, iti eluhlaza, isipinatshi, kunye ne-parsley, kodwa amanqanaba asezantsi xa kuthelekiswa noko kusetyenziselwa ukongezelela.

Ngaba i-PQQ ikhuselekile kwingqondo?

Ukhuseleko luyinto ebalulekileyo ekufuneka iqwalaselwe kuyo nayiphi na isongezelelo. Ubungqina bangoku bubonisa ukuba i-PQQ iyanyamezela kakuhle ebantwini , kwaye akukho ziphumo zimbi zibikwe kwiidosi ezisetyenziswa rhoqo. Nangona kunjalo, ngenxa yokuba uphando lusavela, kungcono ukubonisana neengcali zonyango ngaphambi kokuba uqale isongezelelo, ingakumbi kubantu abaneengxaki zemithambo-luvo okanye abo bakhulelweyo.

isiphelo

Ngoko ke, ngaba i-PQQ ilungile engqondweni? Ngokuqinisekileyo. Ngokukhuthaza i-mitochondrial biogenesis, ukunciphisa uxinzelelo lwe-oxidative, ukukhuthaza ukukhula kwemithambo-luvo, kunye nokuphucula inkumbulo nokufunda, i-PQQ ibonisa ithemba elikhulu njengekhompawundi yokukhusela imithambo-luvo kunye nokuxhasa ingqondo.

Ngelixa izifundo zoluntu ezinkulu zifuneka, uphando olukhoyo luyixhasa ngamandla indima ye-PQQ ekukhuseleni ingqondo, ukugcina ukuba bukhali kwengqondo, kunye nokuthoba umngcipheko wezifo ze-neurodeergenerative. Kubantu abafuna ukwandisa impilo yobuchopho kunye nokuphila ixesha elide, i-PQQ imele enye yezona zinto zinomdla kakhulu ezifunyenweyo kwisayensi yezondlo.