Ngaba i-PQQ ilungile kwingqondo?
Kwinkalo ye-neuroscience yezondlo, iikhompawundi ezimbalwa zitsale umdla ongako IPrroloquinoline Quinone (PQQ). Le khompawundi eyenzeka ngokwemvelo, efunyenwe kukutya okuthile kwaye ifumaneka njengesongezelelo sokutya, iye yanconywa njenge-antioxidant enamandla kunye ne-stimulator ye-mitochondrial biogenesis. Kodwa ngaphaya kweziphumo zayo zezempilo, umbuzo omnye uyaqhubeka ukubamba ingqalelo yabaphandi kunye nabathandi bezempilo ngokufanayo: Ngaba i-PQQ ilungile kwingqondo?
Impendulo ibonakala inguewe onamandla. Izifundo ezivelayo zibonisa ukuba i-PQQ idlala indima ebalulekileyo ekukhuseleni iiseli zobuchopho, ukuphucula ukusebenza kwengqondo, kunye nokunciphisa umngcipheko wokuhla kwemithambo-luvo. Makhe sijonge nzulu ukuba isebenza njani i-PQQ, kutheni ibalulekile kwimpilo yobuchopho, kwaye yintoni etyhilwa yinzululwazi yangoku malunga neenzuzo zayo ezinokubakho.
Ukuqonda iiMfuno zaMandla zeBrain
Ingqondo yomntu lilungu elidinga amandla. Ngaphandle kokumela kuphela malunga ne-2% yobunzima bomzimba, idla phantse i-20% yamandla omzimba ewonke. La mandla enziwa ikakhulu yi-mitochondria, amagumbi amancinci angaphakathi kweeseli. Njengoko sikhula, umsebenzi we-mitochondrial uthande ukwehla, unegalelo ekudinweni, ukucinga kancinci, ukulahleka kwenkumbulo, kunye nokwanda komngcipheko kwizifo ze-neurodeergenerative.
Kulapho PQQ Ngokungafaniyo ne-antioxidants ezininzi ezivele zinciphise iiradicals zasimahla, i-PQQ inamandla awodwa okuvuselela ukudalwa kwe-mitochondria entsha - inkqubo ebizwa ngokuba yi-mitochondrial biogenesis. Ngokuphucula umsebenzi we-mitochondrial, i-PQQ iqinisekisa ukuba i-neurons (iiseli zengqondo) zibonelela ngamandla ezifunekayo ukuxhasa ukufunda, imemori, kunye nokusebenza kwengqondo jikelele.
Ixhasa njani iPQQ kwiMpilo yeBrain
1. I-Mitochondrial Biogenesis kwi-Neurons
Umsebenzi ophilileyo we-mitochondrial ubalulekile ekusebenzeni kwengqondo. Uphando lubonisa ukuba i-PQQ inako lawula izakhi zofuzo ezibandakanyekayo ekubunjweni kwe-mitochondrial, ngokufanelekileyo ukunika i-neurons amandla amaninzi amandla. Oku kwenza i-PQQ ibaluleke ngakumbi ekunciphiseni kwengqondo okunxulumene neminyaka, apho unikezelo lwamandla kwii-neurons luhlala lusengozini.
2. Ukhuseleko olunamandla lwe-Antioxidant
Ingqondo isengozini kakhulu uxinzelelo oluxhamlayo, eyonakalisa i-neurons kwaye ikhawulezise izifo ze-neurodeergenerative ezifana ne-Alzheimer kunye ne-Parkinson. PQQ isebenza njenge i-redox-cycling antioxidant, okuthetha ukuba imolekyuli enye inokuphindaphinda ukuthomalalisa iiradicals zasimahla. Oku kuyayihlula kwii-antioxidants eziqhelekileyo njenge-vitamin C, enokuthi isebenze kube kanye ngaphambi kokuba iphele.
3. IFactor yokuKhula kweNerve (NGF) Ukuvuselela
Enye yezona ziphumo ezizodwa ze-PQQ kukukwazi ukuvuselela imveliso ye I-nerve growth factor (NGF). I-NGF yiprotheyini exhasa ukukhula, ukugcinwa, kunye nokulungiswa kwee-neurons. Ukonyuka komsebenzi we-NGF kuthetha unxibelelwano olomeleleyo phakathi kweeseli zengqondo kunye neplastiki yengqondo ephuculweyo - ukukwazi ukufunda, ukulungelelanisa, kunye nokwenza iinkumbulo ezintsha.
4. Ukuphuculwa kwengqondo
Izifundo zabantu zibonisa ukuba ukuxhaswa kwe-PQQ kunako ukuphucula inkumbulo, ingqalelo, kunye nesantya processing. Umzekelo, kulingo lwezonyango lwaseJapan, abathathi-nxaxheba abathathe i-PQQ iiveki ze-12 bafumana uphuculo olubalulekileyo kwinkumbulo yexesha elifutshane kunye nokucaca kwengqondo xa kuthelekiswa namaqela e-placebo. Xa idibene ne ICoenzyme Q10 (CoQ10), i-PQQ ibonise uphuculo olukhulu ngakumbi ekusebenzeni kwengqondo.
5. Ukukhuselwa kwi-Neurotoxins
I-PQQ ibonise iziphumo zokukhusela iiproteni ze-amyloid-beta, amacwecwe ayingozi anxulumene nesifo sika-Alzheimer. Izifundo zezilwanyana zicebisa ukuba i-PQQ inciphisa ukwakheka kwe-plaque kwaye ithintele i-neurotoxicity, inika ithemba njengenyathelo lothintelo ngokuchasene ne-dementia.
6. Ukuphucula iMood kunye nokulala
Kuyathakazelisa ukuba PQQ ukongezelela kuye kwadityaniswa umgangatho ongcono wokulala, uxinzelelo oluphantsi, kunye nokuphucula ukulawulwa kwemo. Kuba uxinzelelo kunye nokungalali kakuhle kunegalelo elikhulu ekunciphiseni kwengqondo, oku kwenza i-PQQ ibe sisondlo esibaluleke ngakumbi sokuxhasa ubuchopho.
I-PQQ kunye neNgcaciso yeNgcaciso eNxulumene nobudala
Enye yezona ndawo zinomdla kakhulu kuphando lwe-PQQ yindima enokubakho ekucutheni okanye ekuthinteleni izifo ze-neurodeergenerative. Ngelixa kungabikho isongezelelo sonyango, iindlela ze-PQQ - ukusuka ekukhuseleni i-mitochondria ukuya ekunciphiseni umonakalo owenziwe nge-oxidative - zijongana nezinye zezona zizathu zokuwohloka kobuchopho obunxulumene nobudala.
Ngokuxhasa ukusebenza kwe-mitochondrial enempilo, ukunciphisa ukudumba, kunye nokukhusela i-neuron kwiiproteni ezinetyhefu, i-PQQ ibonelela ngeendlela ezininzi zokugcina impilo yengqondo ukuya ebudaleni.
Isebenza njani i-PQQ njengeAntioxidant ebuchotsheni
Ngokungafaniyo ne-antioxidants ezininzi eziye zisetyenziswe emva kokunciphisa i-radical enye yasimahla, i-PQQ inamandla amangalisayo okwenza zityhutyha imijikelo ye-redox emininzi. Oku kuthetha ukuba inokuphindaphinda ukuthoba iimolekyuli ze-oxidative ngaphandle kokuba ingasebenzi ngokwayo.
Kwingqondo, oku kubalulekile: ii-neuron zinobuntununtunu kakhulu kumonakalo owenziwe yi-oxidative, kwaye uxinezeleko lwasimahla lweradical lunxulunyaniswa ngamandla nokuncipha kwengqondo kunye nezifo ezinjenge-Alzheimer's. Ngokugcina a Ikhaka le-antioxidant elihlala ixesha elide, i-PQQ inceda ii-neurons zihlale zisebenza kwaye zomelele.
Ingakanani iPQQ oyifunayo?
Izongezo ze-PQQ eziqhelekileyo zibonelela nge-10-40 mg ngosuku, nangona ezinye izifundo zonyango zisebenzisa ukuya kuthi ga kwi-60 mg. Ihlala ithathwa ecaleni kwe-CoQ10, kuba ezi khompawundi zimbini zisebenza ngokubambisana ukukhulisa impilo ye-mitochondrial.
Imithombo yokutya ye-PQQ ibandakanya i-soy ebilisiweyo (i-natto), i-kiwi, iti eluhlaza, isipinatshi, kunye ne-parsley, kodwa amanqanaba asezantsi xa kuthelekiswa noko kusetyenziselwa ukongezelela.
Ngaba i-PQQ ikhuselekile kwingqondo?
Ukhuseleko luyingqwalasela ebalulekileyo kuyo nayiphi na isongezelelo. Ubungqina bangoku bucebisa ukuba i-PQQ i inyamezeleke kakuhle ebantwini, ngaphandle kweziphumo ebezingalindelekanga ezinkulu ezichazwe kwiidosi ezisetyenziswa ngokuqhelekileyo. Nangona kunjalo, ngenxa yokuba uphando lusavela, kusoloko kulungele ukubonisana nengcali yezempilo ngaphambi kokuba uqalise ukongezwa, ngakumbi kubantu abaneemeko zemithambo-luvo okanye abo bakhulelweyo.
isiphelo
Ke, kunjalo PQQ ilungele ingqondo? Ngokuqinisekileyo. Ngokuvuselela i-mitochondrial biogenesis, ukunciphisa uxinzelelo lwe-oxidative, ukukhuthaza ukukhula kwemithambo-luvo, kunye nokuphucula inkumbulo kunye nokufunda, i-PQQ ibonisa isithembiso esikhulu njengekhompawundi ye-neuroprotective kunye ne-cognitive-support.
Ngelixa izifundo zoluntu ezinkulu zifuneka, uphando olukhoyo luyixhasa ngamandla indima ye-PQQ ekukhuseleni ingqondo, ukugcina ukuba bukhali kwengqondo, kunye nokuthoba umngcipheko wezifo ze-neurodeergenerative. Kubantu abafuna ukwandisa impilo yobuchopho kunye nokuphila ixesha elide, i-PQQ imele enye yezona zinto zinomdla kakhulu ezifunyenweyo kwisayensi yezondlo.
