Lactoferrin Manufacturer

• Ukwazisa iLactoferrin

I-Lactoferrin, i-glycoprotein esebenza ngentsimbi esebenza ngeendlela ezininzi efumaneka kubisi lwezilwanyana ezanyisayo kunye nolwelo olwahlukeneyo lomzimba, ifumene ingqalelo enkulu kuphando lwezenzululwazi ngenxa yemisebenzi yayo eyahlukeneyo yebhayoloji kunye nokusetyenziswa okunokwenzeka. I-Lactoferrin iphezulu kwi-colostrum kunye nobisi, eyafunyanwa kubisi lwebele zizazinzulu ze-MONTREUIJ kunye ne-JOHANSONB ngo-1960. I-Lactoferrin idlala indima ebalulekileyo ekukhuseleni ngaphakathi ngokuthatha intsimbi, eyimfuneko ekukhuleni kwebhaktiriya, ngaloo ndlela inciphisa ukwanda kwe-microbial.

ILactoferrin Yenziwe ngu Yange Biotech inceda ukulawula indlela i-iron efunxeka ngayo emzimbeni isuka emathunjini. Ikwabonakala ikhusela kusulelo olusuka kwiibhaktheriya, iintsholongwane, kunye nokungunda. I-lactoferrin kubisi lwebele kucingelwa ukuba inceda ukukhusela iintsana ezincancisayo kusulelo. Ukongeza, uphononongo lubonise ukuba i-lactoferrin inemisebenzi ye-antibacterial ebanzi, usulelo olulwa nentsholongwane kunye nokuqinisa ukhuseleko.

• Umgangatho woMgangatho weLactoferrin

Ngokutsho kwe-GB1903.17-2016

• imisebenzi

I-Lactoferrin yintsimbi ebopha i-glycoprotein kwi-transferrin, egxile kubisi lomntu kunye nolwaluncelisayo kunye nolwelo olwahlukeneyo oluyimfihlo. Nangona kunjalo, umxholo we-colostrum ngowona uphezulu. Inani elincinci le-lactoferrin likwaqulethwe kumphezulu we-mammalian mucosal, iinyembezi, amathe, amasuntswana e-leukocyte, ijusi yepancreatic, i-bile kunye nolwelo lwamathumbu. Inoluhlu olubanzi lwemisebenzi, kubandakanywa inzala, i-bacteriostasis, i-anti-virus, i-immune regulation, ukukhuthaza ukuxutywa kwesinyithi kunye neminye imisebenzi ekhethekileyo ye-physiological.

1. Intsholongwane

Kuye kwagqitywa ukuba i-lactoferrin yi-agent-spectrum bacteriostatic agent, enokuthintela iibhaktheriya ze-Gram-negative ezifuna isinyithi, njenge-coliform, i-Salmonella, njl. Inokuthintela iibhaktheriya zeGram-positive. Nangona kunjalo, ngokusisiseko ayithinteli ibhaktheriya enemfuno ephantsi yentsimbi, njengebhaktiriya ye-lactic acid.

2. IAntiviral

UPioneer Biotech nguMvelisi weLactoferrin. Idlala indima enkulu ekuxhathiseni iintsholongwane kwinginginya, kwaye inokuthintela intsholongwane ye-immunodeficiency (HIV), i-cytomegalovirus, iintlobo ze-herpesvirus 1 kunye ne-2, intsholongwane ye-hepatitis C (HCV), intsholongwane yomkhuhlane njalo njalo.Ingcaciso enye ye-antiviral mechanism yelactoferrin kukuba i-lactoferrin inokudityaniswa nentsholongwane kunye neeseli zomkhosi, ukuze ithintele indibaniselwano phakathi kwentsholongwane kunye neeseli ezibambayo kunye nokukhusela ezokugqibela kukwenzakala kwentsholongwane.

3. Antioxidant

Ioksijini engaphezulu kweradicals yasimahla emzimbeni yenza i-lipid peroxide, enokonakalisa iiseli kunye nezicubu. Luphawu lokuguga kunye nezifo. ILactoferrin inokubopha ii-iron kwaye ithintele i-lipid oxidation kunye nokusinda kwinguqu yeoksijini yasimahla ebangelwa zii-iron. Zonke ezi zinto zinokunciphisa umonakalo weeradicals zasimahla kwi-elastin eludongeni lwemithambo, ukuze kuthintelwe kwaye kunyange i-atherosclerosis kunye nesifo sentliziyo.

4. Ukulawula ukuphendula komzimba

I-Lactoferrin inokudibanisa kunye ne-lymphocytes, i-monocytes, i-macrophages kunye nezinye iiseli ukuze zidlale imisebenzi eyahlukeneyo. I-Lactoferrin inokuphembelela ukusabela komzimba kwi-humoral, ikhuthaze ukwanda kwe-lymphocyte, ilawule ukuveliswa kweeseli zomongo wethambo kunye nokunciphisa ukudumba. Kwangaxeshanye, i-lactoferrin inokubulala iintsholongwane ngokuvuselela ii-neutrophils ukuvelisa iiperoxide. I-Lactoferrin inokuphembelela ukwanda kweeseli ze-mucosal zamathumbu kunye neeseli ze-spleen kwaye ikhuthaze ukuvuthwa kwamajoni omzimba amathumbu.

5. Ukuthintela uphuhliso lomhlaza.

I-Lactoferrin yi-in vitro i-antiviral ebanzi ye-antiviral ye-virus yabantu kunye nesilwanyana esekwe kwi-DNA / RNA. Ukumelana ne: i-herpes simplex virus type I and II, i-cytomegalovirus, i-virus yokungabikho komzimba womntu, i-virus ye-hepatitis C, i-hantavirus, i-rotavirus, i-poliovirus yohlobo lwe-I, i-virus ye-syncytial yokuphefumula komntu kunye ne-murine leukemia virus.

Inkcazo: https://www.spandidos-publications.com/10.3892/ijo.2021.5265

6. Ukulawula ukufunxwa kwentsimbi

Njengesixabisi sentsimbi, isiphumo sokufunxa se-lactoferrin singcono kakhulu kuneso se-sulfate ye-ferric. I-Lactoferrin inamandla okubopha kunye nokuthutha intsimbi. Inokukhulula i-iron emva kokufikelela emathunjini omntu, enokuthi iphucule eyona nto ifunxayo kunye ne-bioavailability yentsimbi.

7. ILactoferrin yonyango lwe-COVID-19

Kutshanje, izazinzulu zaseMelika zisebenzise itekhnoloji yobukrelekrele bokwenziwa ukujonga uninzi lwamachiza anokujongana ne-COVID-19, kubandakanya ne-lactoferrin.

Ingcaciso: https://www.spandidos-publications.com/10.3892/etm.2020.9402

• Isetyenziselwa i-lactoferrin

1. Isondlo somntwana

yeyona marike iphambili yosetyenziso lwelactoferrin. Nangona kunjalo, amanye amacandelo asebenzisa iipropathi zesondlo kunye nokusebenza kwale proteni.

2. ILactoferrin isetyenziswa ngokubanzi njengesongezelelo sokutya.

Ngokukodwa njenge-immunomodulator. Nangona izenzo zayo zingekaqondwa ngokucacileyo, siyazi ukuba yongeza impendulo yomzimba. Amaphononongo amabini aqhutywe kumavolontiya asempilweni abonise ukuba ukusebenzisa i-lactoferrin ephuma kubisi lwenkomo kuneziphumo ezihle zokugonyela umzimba (kuxhomekeke kwiprofayili yokuqala yenkqubo yomzimba yokuzikhusela yevolontiya). Iziphumo zibonisa ukuba i-lactoferrin ephuma kubisi lwenkomo inokusetyenziswa eklinikhi ukuphucula imeko yokhuselo lomzimba kwizigulana kwaye inokudlala indima ekuqaliseni impendulo yabo yomzimba. Izongezo zeLactoferrin ezithengiswayo ngoku sele zinenqanaba lokucoceka elifikelela kuma-96%.

3. ILactoferrin ikwasetyenziswa kwicandelo lezithambiso

Inokufumaneka kwinani leemveliso zobuhle ezibandakanya ukwenza-up kunye neenwele, ubuso kunye nezinto zokukhathalela umzimba. Ngokomzekelo, i-antibacterial yayo iipropathi zithetha ukuba sisithako esifunwa kakhulu kwizicoci. Ikwasetyenziswa kwiifomyula ze-hairspray zokuhambisa amanzi kunye neenwele ezilula. I-Lactoferrin ikwavuselela i-metabolism yolusu kwaye inesiphumo sokulwa nokuguga ngenxa ye-antioxidant yayo iipropathi ezibamba iiradicals zasimahla.

4. Icandelo lococeko lomlomo likwasebenzisa i-lactoferrin

ILactoferrin inobudlelwane obuluqilima bentsimbi, iyinceda ukuba isebenze njengearhente ye-bacteriostatic. Ngenene yehlisa ubuninzi bee-ion zeferri ezifumaneka simahla, inqanda ukukhula kweebhaktheriya ezithile kunye neengxaki ezinxulumene noko ezifana nokuphefumla kakubi, ukubola kwamazinyo kunye netartar.

Itshati yokugeleza

Indlela yoVavanyo lweLactoferrin

1. Indlela

Sebenzisa isixhobo se-HPLC, fumana i-lactoferrin kwi-280nm kunye nendlela yokulinganisa indawo.

2. Lungiselela umbandela

2.1 Amanzi eBanga loku-1.

2.2 HPLC Acetonitrile.

2.3 0.9%Isisombululo seNaCl

2.4 1% isisombululo se-trifluoroacetic acid: thatha isisombululo se-1ml se-trifluoroacetic acid, xuba ngamanzi e-grade 1 ukuya kwi-100ml, hamba kunye ne-0.45μm yokucoca inwebu.

2.5 isixhobo se-HPLC esine-UV detector.

3. Imeko yeChromatographic

3.1 Uluhlu lwechromatographic:

I-Alltech prosphere C4 300A(150 mmx4.6 mm),

I-Alltech All-guard TM Guard (7.5mm x4.6mm), okanye ikholamu yomsebenzi ofanayo.

3.2 Khangela ubude bobude: 280nm.

3.3 Izinga lokuhamba: 1.0ml / min.

3.4 Ubushushu beKholam: 35°C.

3.5 Umthamo wokutofa: 50μl.

3.6 Iiparamitha ze-Gradient elution.

4. Amanyathelo ovavanyo

Thatha isampulu kunye lactoferrin ireferensi eqhelekileyo 0.1g ngalinye, zombini yongeza 10ml grade 1 amanzi (okanye isisombululo NaCl), uhambe nge 0.45μm filter inwebu, ke sifumana isisombululo isampuli kunye nesisombululo reference. Sebenzisa i-50μl nganye ukuvavanya kwi-280nm, kwaye wenze ixesha elifanayo eliseleyo (malunga ne-10min). Incopho ephambili yincopho yeLactoferrin. Bala yonke indawo encopho phakathi kwexesha eliseleyo kabini. Umyinge weendawo eziphambili kunye nayo yonke indawo encopho luvavanyo lwe-lactoferrin kwiprotein epheleleyo.

• Ireferensi yeChromatogram yeLactoferrin Reference Substance

Uzinzo kunye noKhuseleko

1. Uzinzo: Izinzile phantsi kweemeko ezifanelekileyo (iqondo lokushisa kwegumbi). Uzinzo lwePhepha leDatha liyafumaneka ngesicelo sakho.
2. Ezokhuseleko: Ngokutsho kwe-GARS (Eyaziwa Ngokubanzi njengeKhuselekileyo) Isaziso sase-US, sikhuselekile ukuba sisetyenziswe ngabantu.

I-Lactoferrin ipakethe

Ukupakishwa kweLactoferrin kudlala indima ebalulekileyo ekugcineni ubutsha bemveliso, umgangatho, kunye nobomi beshelufa. Qwalasela ezi mpawu zilandelayo zokupakisha:

Ifakwe kwisingxobo sephepha se-kraft esine-multi-layer kunye nebakala lokutya le-PE yangaphakathi yebhegi, net 25kg/bag. (Ezinye iintlobo zokupakisha ziyafumaneka xa ziceliwe)

Ungayithenga phi I-Lactoferrin?

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